Flemingia on morphine dependence in isolated guinea pig ileum contraction effect of withdrawal.docVIP

 PAGE \* MERGEFORMAT 10 Flemingia on morphine dependence in isolated guinea pig ileum contraction effect of withdrawal Of: Qixiao Chen Wang Hang Qiu Sheng Wang Caiyun [Abstract] observed Flemingia (large leaf decoction on naloxone induced morphine dependence in isolated guinea pig ileum contraction of the role of withdrawal, and its normal acetylcholine induced contraction of isolated guinea pig ileum smooth muscle effects. [ Method] in guinea pig ileum through the production of normal specimens and culture of isolated ileum of morphine dependent group were observed Flemingia decoction on Jia Runa naloxone (Nal1min before and after the contraction of morphine withdrawal effects, and water Flemingia decoction before and after joining the Ach 1min normal ileum contraction. [Results] The decoction of leaves of Flemingia acetylcholine induced contraction of normal guinea pig ileum and naloxone induced morphine withdrawal of guinea pig ileum contraction was inhibited, and its effect was dose-dependent trend. [Conclusion] Flemingia leaf decoction can inhibit morphine withdrawal ileum smooth muscle contraction. [Keywords:] Flemingia, morphine, naloxone, acetylcholine, guinea pig ileum Plants for the Papilionaceae Flemingia Flemingia Flemingia philipinensis trailing roots, the character sweet, slightly astringent, flat, liver or kidney, there expelling wind and dampness, sparse muscle active strengthening sinews and bones, Xiaoyu detoxification effect. The big-leaf experimental study decoction Flemingia naloxone induced morphine withdrawal in guinea pig ileum contraction and on acetylcholine induced contraction of isolated guinea pig ileum effect to the new drug treatment study drug screening and provide clues to the mechanism. 1 Materials and methods 1.1 Animals 20 guinea pigs, male, weight 299.5 +-23.5g, fasting before the experiment 12h. By the Experimental Animal Center of Southern Medical University, license number: SCXK (Guangdong, 2006-0015.