Flavescens Tang on guinea pig ventricular cell electrophysiological effects.docVIP

 PAGE \* MERGEFORMAT 10 Flavescens Tang on guinea pig ventricular cell electrophysiological effects Study: Wen Liu Yanming Xiao-Jing Wang Xuefang [Abstract] [Abstract] Objective: To investigate the Kushen decoction on guinea pig ventricular electrophysiological effects. Methods: Conventional intracellular microelectrode recording technique was flavescens soup in guinea pig ventricular myocytes phase 0 amplitude (APA, action potential duration (APD, 50% repolarization time (APD50, 90% repolarization time (APD90 of influence. Results: (a soup with 20mg/mL of Sophora controls after perfusion group of phase 0 action potential amplitude (APA decreased (P lt;0.05, (2 soup with 40mg/mL of Sophora after perfusion compared with control group 0, the amplitude of action potential (APA decreased (P lt;0.05,50% repolarization time (APD50 decreased (P lt;0.05, (3 soup with 80mg/mL of Sophora after perfusion compared with control group 0, the amplitude of action potential (APA decreased (P lt;0.01,50% repolarization time ( APD50 decreased (P lt;0.01,90% repolarization time (APD90 decreased (P lt;0.05,10 min or so to achieve maximum effect. Conclusion: Sophora soup can inhibit guinea pig ventricular myocytes 0 amplitude, shortened action potential duration . [Keywords:] Sophora, muscle cells / heart, Electrophysiology Technology / heart [ABSTRACT] Objective: To study the electrophysiology Effect of Sophora flavescens. Ait on Ventricles muscle cell of rats.Methods: The action potentials by conventional intracellular microelectrode technique were recorded and the amplitude of action potential (APA), date action potentials (APD) , 50% and 90% of duration of action potential (APD50) and (APD90on Ventricles muscle cell of rats that were perfused with Sophora flavescens. Ait were observed.Results: (1) Comparing the rats perfused with 20mg/mL Sophora flavescens. Ait with control, the amplitude of action potential (APA) decreased (P lt;0.05), (2) Comparing the rats perfuse