For the visceral nociceptive pain pathway regulating the progress of.docVIP

 PAGE \* MERGEFORMAT 13 For the visceral nociceptive pain pathway regulating the progress of [Abstract] for the visceral nociceptive pathway in the regulation of pain can occur in peripheral nerves, spinal cord and spinal cord above the site, and the pathway there is a range of drug treatment on the target. However, only tricyclic antidepressants (TCAs) and the new selective 5-HT reuptake inhibitors (SSRIs) have been proven against the characteristics of visceral nociceptive pain, and the only part of the visceral hypersensitivity of patients. Therefore, target-specific treatment of visceral pain yet to be developed, this paper seeks to potential therapeutic targets for visceral pain and its latest developments and future prospects of treatment may be reviewed. [Keywords:] internal organs; pain; target Pain, particularly in the treatment of visceral pain is still a major clinical problem, at present its treatment is still the mechanism is based on experience rather than research. For neuropathic pain, and irritable bowel syndrome (IBS), tricyclic antidepressants (TCAs) and anticonvulsant drugs has been proven to be effective and, to some extent, and selective 5-HT reuptake inhibitors (SSRIs) similar to the role of . However, the mechanism of action of these drugs and the site remains unclear. Therefore, the multi-target drugs acting on a number of points possible in the short term the best choice for treatment of visceral pain. Nevertheless, the evidence leads us to believe there will appear a better treatment programs. A transient-type receptor potential ion channels (TRPV) and protein kinase receptor (PAR) TRPV  1 is a rather interesting therapeutic targets for visceral pain. Hammer et al [1] The latest research shows that subjects Enteral capsaicin (exogenous ligands and TRPV  1 markedly agents) show a variety of symptoms, which reflects the spinal cord and the vagal afferent nerve expressed TRPV  1 ; capsaicin-induced visceral hypersensitivity