Gabapentin treatment of children with intractable epilepsy Efficacy.docVIP

 PAGE \* MERGEFORMAT 14 Gabapentin treatment of children with intractable epilepsy Efficacy Author: Ping Song, Liao Jianxiang, Zhang cross-sheng, WANG Xin-juan, Hu Yan, Chen Li, Li Bing, Huang iron bolt, Xiao Zhitian, Chengrong [Abstract] Objective: To observe the domestic novel antiepileptic drug gabapentin (Diego force) on the efficacy of children with refractory epilepsy. Methods: an open, forward-looking approach, 7 months continuously enrolled in the hospital and Epilepsy Center, the same doctor (Corresponding author) Department treatment of children with refractory epilepsy patients to obtain parental consent and follow-up. Observe the effect of seizure control and medication side-effects. Gabapentin starting dose 20 ~ 30 mg / kg [(28.6 ± 7.5) mg / kg], gradually increase the amount, 3 d increase to the target dose. Results: 42 patients enrolled, 37 males and 5 females. All age of onset before the age of 18, into the group during 1.7 years of age to 23 years old, with a median age of 10 years. Partial epilepsy in 37 cases, 5 cases of symptomatic infantile spasms. Into the group of more than four kinds of pre-used an average of 6.5 kinds of anti-epileptic drugs (median 6). These two cases of illness due to significantly increased within 1 week to abandon treated with gabapentin. 1 cases of home automatically abandon the use of gabapentin. Treatment observation period is at least 20 d, a maximum of 84 months (7 years), mean (589.5 ± 967.6) d, median 90 d. Nine cases can be maintained long-term medication [(76.9 ± 17.3) months, median 83 months], 7-year retention rate 21% (9 / 42). 5 cases (12%) seizures completely stopped and the remaining episodes with pre-treatment. Treatment of 10 cases of attacks increase, of which 4 cases with the gabapentin. 10 cases began to effective, within 1 month of onset of relapse, such as that before treatment (the body of the emergence of drug resistance). Of infantile spasms is invalid. 3 cases of mild sleep increase, d