Ginkgo biloba extract on lipid fatty liver in rats with insulin resistance induced by the intervention of.docVIP

 PAGE \* MERGEFORMAT 22 Ginkgo biloba extract on lipid fatty liver in rats with insulin resistance induced by the intervention of Of: Xi Yun Xia Jinwei Huang Gaozhong Xiuzhen present status and Zhong Yuan Ye [Abstract] Objective To investigate insulin resistance (IR and lipid metabolism, the relationship between fatty liver, as Ginkgo biloba extract for the early prevention of fatty liver and provide experimental basis for further treatment. Methods healthy adult SD male rats 40, Weight 200 ~ 250 g, adaptive feeding rats after No. 1 w, rats were randomly divided into normal group, model group, Ginkgo biloba group, positive medicine group; weekly monitoring of blood glucose and body weight, after the intervention in 12 w animals were killed to collect blood for blood biochemical parameters (FBG, 2 hPG, FINS, PINS, lipids, liver lipids and liver enzymes; and insulin sensitivity index (ISI) values to assess the success of the modeling; and liver morphology observation; Finally, the statistical analysis. Results compared with the normal group, model group ISI was decreased, blood glucose, blood lipid levels (P lt;0.05 or P lt;0.01; with model group, the ginkgo biloba group, positive medicine group The ISI value increased, decreased blood glucose and lipid levels, statistically significant difference (P lt;0.05 or P lt;0.01, Compared with normal group, model group, body weight, liver weight ratio and liver tissue TG, FFA, ALT, AST increased significantly; treatment liver TG, FFA significantly reduced, but still higher than the normal group (P lt;0.05, model group, liver tissue MDA activity was significantly increased total antioxidant capacity (T AOC) and SOD activity was significantly decreased (P lt;0.01), compared with model group, the treatment of liver tissue SOD activity and elevated T AOC, MDA activity decreased (P lt;0.01), T AOC and MDA was negatively correlated (r =- 0.312 , P lt;0.01), model group showed a diffuse liver steatosis, lobular inflam