Glycyrrhiza adverse reaction.docVIP

 PAGE \* MERGEFORMAT 16 Glycyrrhiza adverse reaction Abstract the main active ingredient in licorice is glycyrrhizin, glycyrrhizic acid, if the rational application will play a role, but the improper application of toxic or worsen disease, so the toxicity of licorice should attract attention. Keywords: liquorice; toxic side effects; the use of taboo Licorice is a very commonly used drug clinicians, open finished prescriptions, doctors tend to blindly Xinshou added licorice. Southern physician Hongjing, said: “This is the most public drug king of grass by parties who do not rare,” therefore, “10 square nine grass,” says that he respectfully called “the old country.” It is sweet natured, sang, slightly cold, to heat detoxification, lungs and expectorant; Sunburn is tepid, can Qi Sheng Jin, ease herbs, urgency and pain. But in recent years as the deepening of the study, licorice more and more reports of toxic side effects. Are summarized below. An overview of licorice toxicity The 20th century, 50 years, “German Medical Weekly” reported that licorice symptoms of acute poisoning, there is an increase in blood pressure and blood volume caused by headache, dizziness, palpitations, breathing and cardiac palpitations caused by potassium reduction, body fatigue, severe abdominal distension. Report of the 20th century, 60 years Reppas, licorice good effect on the gastric ulcer, but it will cause high blood pressure and swelling. In 1968, Cohen reported for patients with hepatitis glycyrrhizin (423 mg / d), the hepatitis improved, but high blood pressure, caused by low potassium and low potassium of Tan Bing. The glycyrrhizin dose of 2 ~ 5 g / kg (PO), the electrolyte can be seen the role of (ip, sodium retention and potassium excretion), licorice hemolytic weak. Japanese Ministry of Health regulations provides that the glycyrrhizin in doses greater than 100 mg / d, or licorice in doses greater than 2.5 g / d (iv) of the patients m