Gomi long-term toxicity study of musk pill.docVIP

 PAGE \* MERGEFORMAT 6 Gomi long-term toxicity study of musk pill Author: Ren Yuan, Kampot Dong-Zhi, Ma, Wu Cathay, Zhi-Wang Wang, Feng Liu Lin, Wang Ruiqiong [Abstract] Objective To study the long-term administration of flavors musk pill toxicity. Methods to 0.030,0.075,0.225 g / kg 3 doses consecutive 21 d to rats gavage, the rats were the general situation, hematological, blood biochemical indicators and the main organs histopathological observation and examination. Results dose animals in each group during the appearance of signs, general activities, no abnormal situation, changes in body weight and feed consumption compared with the control group, no statistical significance; treatment group animals, hematological, blood biochemical indicators and the control group showed no statistical significance; treatment group animals, heart, liver, spleen, lung, kidney and other major tissues revealed no pathological changes in drug-induced abnormalities. Conclusion Under the experimental conditions was not observed in rats with mixed musk pill apparent toxicity. [Keywords:] Gomi musk pill; rat; long-term toxicity Gomi musk pill is contained in Tibetan medicine in China Pharmacopoeia varieties of the drug from the musk, myrobalan, black Aconitum, costas, possession of iris composition [1], has anti-inflammatory, analgesic, the efficacy of Qufeng for tonsillitis, angina, influenza, anthrax, arthritis, neuralgia, stomach pain, toothache and other diseases [1]. Drug prescription medicines contain toxic black Aconitum (Ranunculaceae plant for the possession of Aconitum Aconitum balfourii Stapf, or iron bars, hammers Aconitum szechenyianum Gay.’s Dried root [1]), clinical lead poisoning are also taking the drug reported in the literature [2 ]. In this experiment the main temples of the Gannan Tibetan Medicine Co., Ltd., Gansu Province Wuwei production of musk pills were fed 21 d of long-term toxicity studies, now part of the test results are summarized below. A test