Gui Zhi decoction on atherosclerosis of vasoactive substances.docVIP

 PAGE \* MERGEFORMAT 11 Gui Zhi decoction on atherosclerosis of vasoactive substances Study: Duhui Bo Chen Yanjing Wang Jianwei Jiao Xue Guiping [Abstract] Objective: Gui Zhi Tang on long-term high fat diet induced atherosclerosis model of rat blood lipids and vascular endothelial active factors. METHODS: 48 rats were randomly divided into 5 groups: normal group (normal diet , n = 8, the model group (high fat diet fed rat model of atherosclerosis, n = 10, positive control group (model group fed plus simvastatin, n = 10, Gui Zhi Tang low concentration group (model Group Guizhi soup 10g / (kg d orally, n = 10, Gui Zhi Tang high concentration group (model group Guizhi soup 20g / (kg d orally, n = 10. 14 weeks by light microscopy observation of feeding arteries plaque formation was detected after serum total cholesterol (TC, triglycerides (TG, high density lipoprotein cholesterol (HDL-C, low density lipoprotein cholesterol (LDL-C, measured by radioimmunoassay of plasma endothelin (ET and vascular tone factor (Ang content. Results: Gui Zhi Tang continued treatment for 6 weeks, compared with model group, serum TG, TC, LDL-C concentration decreased (P lt;0.01, HDL-C concentration (P lt;0.01, ET, and Ang decreased (P lt;0.01. Conclusion: Gui Zhi decoction can lower blood lipid and vascular endothelial activity factor, vascular endothelial protection, improve endothelial function. [Keywords:] Gui Zhi Tang, atherosclerosis, endothelin peptide, angiotensin [ABSTRACT] Objective: To investigate the effct of Guizhi-tang in improving vascular endothelial function of atherosclerosis rats.Methods: 48 Sprague-Dawley (SD) rats were divided randomly into five groups which were control group, atherosclerosis group, simvastatin group, Guizhi -tang [10g / (kg d] group and Guizhi-tang [20g / (kg d] group.The Total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL) , Endothelin and Ang were observed for each group.Res