Han population in Ningxia mannose-binding lectin gene polymorphism associated with hepatitis B.docVIP

 PAGE \* MERGEFORMAT 13 Han population in Ningxia mannose-binding lectin gene polymorphism associated with hepatitis B Of: hp Tong, Li Jun, LI Ya-li, Wang Yujiong [Abstract] Objective To investigate the Han population in Ningxia mannose binding lectin (MBL) gene polymorphisms and hepatitis B related. Methods PCR-RFLP method detected 111 cases of Chinese Han healthy people in Ningxia, 82 cases of hepatitis B patients with MBL gene polymorphism distribution and other Chinese Han population with the distribution of MBL gene polymorphism were compared. Results Han population in Ningxia, detected only two alleles: wild-type A and variant B, variant not detected C, D allele, found that healthy people with MBL gene polymorphism in hepatitis B patients no significant difference. Conclusion MBL gene polymorphism and hepatitis B are not related, but the MBL gene polymorphism in Ningxia and Guangdong Han Han There was a significant difference. [Keywords:] hepatitis mannose binding lectin gene polymorphism ABSTRACT: Objective To explore the association between the hepatitis B virus (HBV) infection and mannose binding lectin (MBL) gene polymorphisms in Han population in Ningxia. Methods MBL was genotyped using PCR-RFLP in 82 patients affected by HBV and 111 unrelated controls from Ningxia. And we compared the genotype and allele frequency of MBL in different Han population in China. Results We only found the A and B allele. There were no significant differences in MBL polymorphism distribution in patients and controls. Conclusion There was no association between MBL polymorphism and hepatitis B. And there was significant difference in MBL polymorphism distruibution among the Han population in Ningxia and Guangdong. KEY WORDS: hepatitis B virus (HBV); mannose binding lectin (MBL); gene polymorphism Mannose binding lectin (mannose binding lectin, MBL) is to participate in the host innate immune defense molecule, which can be activated through the lectin pathway