Hand perfume extract and volatile oil toxicological studies.docVIP

 PAGE \* MERGEFORMAT 10 Hand perfume extract and volatile oil toxicological studies [Abstract] Objective To conduct toxicological studies on the hand incense, including hand perfume extracts acute toxicity experiments and hand fragrant volatile oil of acute toxicity test. Methods hand perfume extracts with the greatest concentration of 4.706 g / ml, maximum dose of 0.8 ml/20 g of mice gavage to measure hand perfume extracts the maximum tolerated dose in mice. Using Horn’s (Horn) method, mice were randomly divided into four groups, according to 1.0,2.15,4.62,10.0 ml / kg-dose gavage of mice were measured hand fragrant volatile oil lethal dose in mice. The results of hand perfume extract (converted dose dependent) on the mouse maximum tolerated dose: 188.2 g / kg, hand fragrant volatile oil LD50 for mice: 2.37 ml / kg. Conclusion hand perfume extracts in mice had no significant acute toxicity, hand fragrant volatile oil of certain acute toxicity in mice. [Keywords:] hand incense maximum tolerated dose acute toxicity of lethal dose Abstract: ObjectiveTo study the acute toxicity of water soluble extract and the volatile oil of Coleus amboinicus Lour. (CAL) in mice.MethodsThe maximum administration dosage (concentration 4.706 g / ml, dose 0.8ml/20g) of the water soluble extract were determined by iq administration in mice. The maximal tolerance dose (MTD) of water soluble extract of CAL to mice was measured. Using Horn’s method, mice were randomly divided into four groups and given different doses (1.0, 2.15, 4.62, 10.0 ml / kg ). LD50 of volatile oil of CAL to mice was measured. ResultsMTD of water soluble extract of CAL was 188.2 g / kg, and LD50 of volatile oil of CAL was 2.37 ml / kg. ConclusionWater soluble extract of CAL is not acutely toxic to mice , and volatile oil of CAL is acutely toxic to mice in a certain degree. Keywords:: Coleus amboinicus Lour.; Acute toxicity; The maximal tolerance dose; LD50 Hand Xiang Coleus amboinicus Lour., Alias left inc