Hand foot and mouth disease with viral encephalitis analysis of 107 cases.docVIP

 PAGE \* MERGEFORMAT 12 Hand foot and mouth disease with viral encephalitis analysis of 107 cases [Abstract] Objective To investigate the foot and mouth disease with clinical features of viral encephalitis, and diagnosis and treatment. Methods 682 cases of hand, foot and mouth disease in 107 patients with viral encephalitis complicated by the clinical data of patients were analyzed retrospectively. Results of 107 cases in children were acute onset, fever and rash. HFMD rash buttocks were 43 cases, 18 cases of skin rash associated with the legs, accompanied by systemic rash in 5 cases, 6 cases of disturbance of consciousness (5.6%), seizures in 3 cases (2.8% ), meningeal irritation sign (+) 68 cases (63%), combined with gastric bleeding in 2 cases, 2 cases of respiratory failure, pulmonary hemorrhage in 2 cases, 1 death .107 patients underwent cerebrospinal fluid examination, of which 98 cases of elevated CSF pressure (91%), cerebrospinal fluid routine and biochemical abnormalities in 65 cases (60%) .102 routine EEG, abnormal changes in 88 cases (86%) .102 routine head CT examination showed no abnormality .107 cases are used comprehensive treatment, early to intravenous ganciclovir, and dexamethasone, mannitol, methyl prednisolone for severe cases, intravenous gamma globulin infusion therapy. cured or improved in 106 cases (99%), 2 cases with neurogenic pulmonary edema, pulmonary hemorrhage in 1 patient died. Conclusions HFMD outbreaks occur, complicated by viral encephalitis, with a young, high-risk, acute onset, rapid development of features, the vast number of cases can be cured, and no significant sequelae. Severe cases is small, but high mortality, should strengthen awareness of the disease, early diagnosis and timely treatment is key to successful treatment. [Keywords:] hand, foot and mouth disease / diagnosis; Encephalitis / virology; infectious diseases; gamma globulin / therapeutic use, Coxsackie virus, Methylprednisolone / therapeutic use, Child