Heavy ion cancer treatment two advantages.docVIP

 PAGE \* MERGEFORMAT 13 Heavy ion cancer treatment two advantages Authors: Chuan-Ling Guo, Ju-Fang Wang, Xiao-Dong Jin, Wei Wei, Li Jian 【Abstract】 Objective To observe the two kinds of human cancer cells  human hepatoma cells SMMC  7721, and A375 human melanoma cells of high LET12C6 ions and γ-ray irradiation sensitivity and sub-sub-effect, observed heavy ion treatment of tumors and the feasibility of advantage. Method to two kinds of in vitro culture of different organizations from the body with a high radiation resistance of malignant cells in the experimental object, respectively 12C6 and γ-ray doses of 0 ~ 6Gy different points of single and fractionated irradiation, using clone survival France statistics cell survival fraction. The results, whether single or fractionated irradiation, 12C6 cell survival after irradiation two kinds of scores were significantly lower than the γ-ray irradiation of cells, but also the sub-sub-effect of heavy ions is markedly lower. Conclusion The results showed that heavy ions in cancer therapy are two important advantages, namely, tumors with high and low sub-sub-lethal effects, indicating heavy ion irradiation-induced low-repair phenomenon, allows more efficient tumor radiotherapy. Keywords: tumor cells; heavy ion; survival fraction Keywords:: Tumor cells; Heavy  ions; Survival fractions Radiation therapy is an important means to treat malignant tumors. Conventional radiation therapy used in γ, X-ray and electron beam into the human body resulting from the increase of dose with depth exponential decay of tumors and normal tissues have some before and after in vitro. As the dose distribution of heavy-ion Bragg peak, enabling high-absorbed dose, are concentrated in the tumor site, thereby effectively protecting the surrounding healthy tissue, and has a high relative biological effectiveness, repair, and low efficiency in the radiation therapy on the ideal. 70 mid-20th century, the United Stat