Hematological disorders in patients with systemic lupus erythematosus and research progress of the mechanism.docVIP

 PAGE \* MERGEFORMAT 16 Hematological disorders in patients with systemic lupus erythematosus and research progress of the mechanism Of: Luoxiong Yan, Wu Fengxia, Wu Lijun, Yuan Guohua [Keywords:] systemic lupus erythematosus; blood system Systemic lupus erythematosus (SLE) is a multi-system involvement, multi-organ autoimmune disease, often involving the blood system, mainly as anemia, or leukocytosis, thrombocytopenia. SLE patients in some stage of their disease It may occur one or more abnormal blood system, and initial symptoms appear, and the lack of characteristic skin, joint, kidney and other damage to the performance, often difficult to identify. Therefore, understanding of the blood system damage in SLE patients with the clinical characteristics and mechanism , on the timely diagnosis and proper treatment of the blood system damage in SLE patients is important. 1 SLE incidence of hematological abnormalities SLE is more common occurrence of abnormal blood system, almost all of the SLE patients at some stage in their disease may occur one or more abnormal blood system, of which the most common anemia, the incidence of anemia can be as high as 73% ~ 90 %, the severity of anemia and disease duration and severity of the disease, mostly mild to moderate anemia, severe anemia, a few [1]. about 50% may have neutropenia, 25% and 50% had mild thrombocytopenia, 5% ~ 10% had severe thrombocytopenia, pancytopenia (PCP) by approximately 5% [2]. Review of domestic and international data found SLE combined blood system damage accounted for 75% ~ 86.2%, and anemia 19% ~ 57%, leukocyte reduction of 11% -75%, thrombocytopenia 7% to 30% [3]. 2 SLE-related mechanism of abnormal blood system 2.1 The mechanism of anemia blood system SLE anemia is a manifestation of the most common, about 60% to 80% of the activity of SLE patients have varying degrees of anemia, the incidence of anemia was reported that up to 98%, anemia and the severity and duration of d