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Hepatitis B virus antigens in clinical application of PreS1
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Hepatitis B virus antigens in clinical application of PreS1
[Keywords:] Hepatitis B virus;, DNA;, PreS1 antigen;, the clinical significance of
Clinical application value of HBV PreS1 antigen
[Abstract] AIM: To evaluate the clinical significance of detecting PreS1 antigen of hepatitis B virus (HBV). METHODS: HBsAg positive serum specimens (n = 1000) from inpatients and outpatients were collected, then detected for PreS1 antigen and HBV DNA by fluorescence quantitative polymerase chain reaction (FQPCR). RESULTS: The total PreS1 positive rate was 52.0%, the HBVDNA positive rate was 50.8%, and the HBeAg positive rate was 21.0%. The total positive rate of PreS1 was higher distinctly than that of HBeAg. The total accordance rate between PreS1 and HBVDNA was 94.4%. CONCLUSION: PreS1 is more sensitive than HBeAg when as a serological index of HBV infection and reproduction. Determination of PreS1 has a great application value in diagnosis and treatment of hepatitis B. PreS 1 could be taken as a new serological indicator for infectivity and replication of HBV.
[Keywords] HBV; DNA; PreS1; clinical significance
[Abstract] Objective: To evaluate the detection of hepatitis B virus antigen PreS1 the clinical application value. Methods: The clinical submission of the 1000 copies of hepatitis B virus surface antigen (HBsAg)-positive serum specimens PreS1 antigen detection, while determined to use FQPCR to HBVDNA. Results: PreS1 total positive rate was 52.0%, HBVDNA positive rate was 50.8%, HBeAg-positive rate was 21.0%. PreS1 total positive rate was significantly higher than the rate of HBeAg-positive. PreS1 with HBVDNA the total coincidence rate was 94.4%. Conclusion: PreS1 antigen as a hepatitis B infection and replication is higher than the sensitivity of serological indicators of HBeAg, hepatitis B to the prompt development of the disease and the prognosis of patients has important clinical significance. PreS1 can be used as a new infectious hep
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