Hepatocyte growth factor and high blood pressure the relationship between atherosclerosis.docVIP

 PAGE \* MERGEFORMAT 9 Hepatocyte growth factor and high blood pressure the relationship between atherosclerosis Keywords:: hepatocyte growth factor in high blood pressure atherosclerosis insulin-like growth factor-transforming growth factor-β Hepatocyte growth factor (hepatocyte growth factor, HGF) is a stromal cell-derived factor as a multi-functional. It can regulate cell growth and movement, promoting the occurrence of a variety of cell morphology is epithelial cells and stromal cells of the body fluids, the interaction medium, in the embryonic growth, tumor formation and progress of the organization play an important role [1,2]. In addition to a large number of HGF produced by the liver and released into the blood, but also from embryonic lung fibroblast cell line were isolated, it also known as scatter factor (scatter factor) or lung fibroblast-derived growth factor (fibroblast-derived growth factor) [3 ]. 1 HGF generation 1.1HGF generated site HGF was originally isolated from plasma, was widely considered to be released from the liver injury in a hormone-like active substance-specific target organ is the liver. Now in the adult skin, lungs, gastrointestinal tract, fibroblasts and embryonic lung fibroblasts confirmed that HGF gene expression [4], HGF receptor c-met gene expression is a product proven in the brain, liver, etc. organ in both c-met gene expression [5]. 1.2 HGF produced by conditioning First of all, cytokines IGF-1, TGFβ 1, prostaglandins, etc. can be adjusted hepatic stellate cells HSC (hipatic stellate cells) and fibroblasts in HGF production. IGF-1 and prostaglandin E1, E2, I2 can stimulate vascular smooth muscle cells (VSMC) produce HGF [6]; TGFβ 1 reduces the HSC and fibroblasts in HGF gene transcription and protein expression [7,8]. Thus, IGF-1 and TGFβ 1 in the HGF gene expression of HSC from the role of mutual antagonism. Research shows that: In the HGF gene promoter region upstream of the existence and other regulatory factor