Herbal Diabetes Dan on glucose metabolism in experimental diabetic rats enzyme activity of.docVIP

 PAGE \* MERGEFORMAT 13 Herbal Diabetes Dan on glucose metabolism in experimental diabetic rats enzyme activity of Author: Yang Hongli Zhang Hongxin Wang Yan, Lu Shulan Sun Shumin Zhang Weiwei Lan will [Abstract] Objective To study the compound traditional Chinese medicine - herbal medicine Diabetes Dan on glucose metabolism in type 2 diabetic rats a key enzyme hexokinase, malate dehydrogenase activity, providing a scientific basis for clinical medicine. Methods fat, high sugar feed, plus small-dose streptozotocin (STZ, 25 mg / kg, intraperitoneal injection) method to establish rat model of type 2 diabetes, respectively, herbal medicine and Western medicine metformin Diabetes Dan intervention, each Tail blood test over the weekend to take fasting blood glucose values. After 4 weeks, rats were detected by fasting plasma glucose, muscle hexokinase (HK) and liver malate dehydrogenase (MDH). Results Dan Herbal Diabetes Treatment can significantly reduce blood glucose in diabetic rats, its muscle tissue HK, liver MDH activity in comparison with the model group were significantly different. Conclusion Chinese herbal compound - Herbal Diabetes Dan lowering blood glucose may be one mechanism of action, directly or indirectly enhance the activity of glucose oxidation and decomposition; herbal medicine against diabetes, Diabetes Dan on weight loss have a certain effect. [Keywords:] Herbal Diabetes Dan; diabetes; glucose metabolism; hexokinase; malate dehydrogenase Abstract: ObjectiveTo study the effect of Chinese Herbal Compound-Bencao Xiaoke pill on the activity of key enzymes - hexokinase and malate dehydrogenase in the carbohydrate metabolism of type 2 diabetic rats and provide scientific basis for clinical application.MethodsType 2 diabetic rat model was built by small dose injection of streptozotocin (STZ) (25 mg / kg, intraperitoneal injection) and intake of high lipid die. After the model was established, the rats with diabetes were treated with Compound-Benca