Hereditary corneal biological characteristics of mice.docVIP

 PAGE \* MERGEFORMAT 11 Hereditary corneal biological characteristics of mice Author: Shun-Xing SUN Li-Chun Shao Yi-xiang [Abstract] Objective: To study mutagenesis by ENU obtained by means of hereditary corneal mice B6-Co’s biological properties. Methods: Comparison of genetic keratopathy in mice with normal B6 mice reproductive indexes, growth and development parameters, B6-Co different phenotypes between the organ weight, organ indices, blood, urine routine, as well as the similarities and differences in behavior . Results: B6-Co infertility rate of 22% in mice, with an average litter size 5.62 ± 2.55, with the survival rate of 56.59 ± 41.22 from the milk was significantly lower than in B6 mice, while the birth interval of 29.50 ± 10.50 compared with normal B6 mice Tian short. B6-Co mice within 2 weeks after birth, growth and development are basically consistent with normal B6 mice, 2 weeks later, their growth is slower than normal B6 mice. B6-Co male and female mice between the eyes, lungs, thymus, adrenal organ index difference statistically significant. B6-Co phenotypic abnormalities in mice and B6-Co phenotype compared with normal mice, lung, adrenal gland, uterus, testis organ coefficient of difference statistically significant. B6-Co phenotypic abnormalities in mice mice in hemoglobin and red blood cell count is different from B6-Co on the phenotype of normal mice. Balance beam performance scores: B6-Co phenotype of normal mice, 3.50 ± 0.69, B6-Co single-lens reflex in mice 2.17 ± 0.78, B6-Co eyes mice 1.87 ± 0.80 in order of decreasing, and the degree of corneal lesions negative correlation. While grasping the rope and the nest experiments, three groups no significant differences in the performance. Conclusion: Because of genetic mutations leading to corneal decreased reproductive performance of mice, growth and development are affected. B6-Co Phenotype of mice there are differences between the organ coefficient, blood of a number of indicator