High Performance Liquid Chromatography in the application of traditional Chinese medicine pharmacokinetics.docVIP

 PAGE \* MERGEFORMAT 9 High Performance Liquid Chromatography in the application of traditional Chinese medicine pharmacokinetics [Keywords:] high-performance liquid chromatography pharmacokinetics of traditional Chinese medicine High performance liquid chromatography is used high-pressure infusion pump will require the mobile phase pumped into the sample with filler column chromatographic method for separation and determination. For segregation analysis of volatile low thermal stability of polymers, as well as large molecular weight difference of ionic compounds, is extremely beneficial. Determination of plasma concentration pharmacokinetics of modern traditional Chinese medicine research methods commonly used [1], including a clear single flavor component indicators herbs and Chinese herbal compound studies. Delivery of drugs through a certain way to join the body, they can through the monitoring of drugs as well as some elements of endogenous target concentration in the blood changes in the analysis of drugs, such as amino acids, proteins, nucleic acids, lipids, vitamins, antibiotics, alkaloids and so on. High-performance liquid chromatography with separate high efficiency, rapid analysis with high sensitivity, in the modern pharmacokinetic studies have been widely used. In the pharmacokinetic analysis of the process the need for clear indicators of the amount of ingredients to reflect the distribution of information to monitor the excretion of drugs, as well as endogenous changes in composition of indicators to compare the factors influencing drug effects, guiding rational drug use. High-performance liquid separation of analytical tools from a body fluid or tissue can be reflected in the amount of information. But the determination of the specificity, accuracy, sensitivity will directly affect the pharmacokinetics of accuracy, so in order to meet the requirements of the different analytical objects often require multiple types of detectors. In this pap