Histiocytic necrotizing lymphadenitis clinicopathological analysis of 21 cases.docVIP

 PAGE \* MERGEFORMAT 10 Histiocytic necrotizing lymphadenitis clinicopathological analysis of 21 cases [Abstract] Objective histiocytic necrotizing lymphadenitis (HNL) clinical and pathological features and differential diagnosis. Methods Retrospective analysis of 21 cases of HNL in patients with clinical and pathological data and immunohistochemical findings. Results in 21 cases, male 6 cases and 15 female. in patients with cervical lymph nodes with fever, the clinical features of peripheral blood leukopenia. pathology: Lymph node status was broken, the lymph nodes clearly see the boundary of debris necrosis, cell proliferation and deposition of cellulose not associated with neutrophil infiltration. Conclusion HNL clinical rare, more common in young women. have their clinical and pathological features, histological and immunohistochemical examination is an important means of diagnosis of HNL, often misdiagnosed as malignant lymphoma . [Keywords:] Histiocytic necrotizing lymphadenitis of Clinical Pathology, immunohistochemistry Histiocytic necrotizing lymphadenitis (histiocytic necrotizing lymphadenitis, HNL), also known as subacute lymphadenitis, Kikuchi (Kikuchi) disease is a benign self-limiting disease, clinical manifestations of high fever, neck lymph nodes, pathological and easy be confused with malignant lymphoma, misdiagnosis rate of up to 40% [1]. The author of 21 patients with clinical and pathological data of patients with HNL and immunohistochemical analysis of examination results and to investigate its clinical and pathological features, diagnosis and differential diagnosis, aims to in raising awareness about the disease. 1 Materials and Methods 1.1 General Information Our hospital in January 1995 to 2007 12 HNL 21 pathologically confirmed cases, 6 males and 15 females, aged 15 to 56 years, with an average of 29 years. There were 17 patients with unilateral or bilateral neck multiple lymph nodes nodes, 4 cases with cervical, subma