Homatropine hydrobromide in situ gel irritating and pharmacodynamics of.docVIP

 PAGE \* MERGEFORMAT 17 Homatropine hydrobromide in situ gel irritating and pharmacodynamics of Author: Jiang Xin-dong, Wang Qiang, Wang Tong, Sun Baiwang 【Abstract】 Objective: To study the in situ gel Homatropine Hydrobromide eye irritation and pharmacodynamics. Methods: 18 rabbits were randomly divided into two groups, respectively eye irritation test and pharmacodynamic studies. Each group was divided into hydrobromide Homatropine in situ gel group, hydrobromide Homatropine eye drops group and the saline control group, three sub-groups, slit-lamp microscope ocular response to the situation, strabismus tape measure pupil diameter at different time points. Results: The in situ gel Homatropine hydrobromide multiple doses, the slit-lamp microscopic observation of rabbit corneas without opacity, iris and conjunctiva was no swelling, congestion, swelling and other abnormalities. Histopathological examination showed that rabbit eye after administration, compared with the saline treatment group were no significant differences in histopathological changes. Pharmacodynamic results showed that in situ gel Homatropine hydrobromide dilation time of up to 8 h. Conclusion: Homatropine Hydrobromide in situ gel is safe and can effectively extend the drug release time. Keywords: in situ gel; irritating; hydrobromide Homatropine; Pharmacodynamic In recent years, with the development of bio-pharmacy and eye pharmacokinetics after administration of in-depth study found that solution by staying there a short time, and low bioavailability problems [1], such as eye drops trickle-down eye, the Blink of the eyelids and tear due to the secretion of only 1% ~ 10% of the drug to reach the eye through the cornea to play a role, the need to increase the number of drug delivery to improve the bioavailability. The use of ophthalmic preparations, drug through nasolacrimal duct into the nasal cavity and digestive tract was eventually systemic absorption, so simply