Hypertension and insulin resistance study.docVIP

 PAGE \* MERGEFORMAT 6 Hypertension and insulin resistance study [Keywords:] Hypertension / etiology; insulin resistance / etiology; Diabetes According to epidemiological investigation, patients with essential hypertension groups often have different degrees of hyperinsulinemia and glucose and lipid metabolism disorders, such endocrine metabolic disorders in hypertensive disease occurrence and development play an important role [1] . In which insulin resistance (IR) may be one of the foundations of their common pathogenesis [2]. Hyperinsulinemia caused by high blood pressure mechanisms include: increased renal tubular sodium and water re-absorption; to stimulate the sympathetic nerve activity; regulating ion transport of Na  K  ATP enzyme and Ca  ATP activity decreased; increase in vascular and aldosterone on vascular tension reactive-Ⅱ ; interfere with lipid metabolism, increasing lipid metabolism disorder, and as growth factors to stimulate the generation of arterial wall and proliferation of cellular components, leading to atherosclerosis. Jun Qin et al [3] that the IR-induced high blood pressure through the following several aspects: ① sodium retention: Insulin resistance, renal tubular sodium reabsorption increased, while no significant effect on glomerular filtration rate, causing body sodium retention, leading to elevated blood pressure; ② sympathetic nerve activity increased: insulin in the physical and super-physiological level of sympathetic nerve has a stimulating effect. In the IR state, blood glucose, insulin levels increased, cells in the hypothalamus automatic adjustment of glucose uptake and metabolism increased, the central role of inhibitory brain stem sympathetic weakened, leading to increased sympathetic activity, thereby stimulating the heart, blood vessels and kidneys, so that blood flow decrease in peripheral resistance increased, high blood pressure; ③ Na  K  ATP and Ca2  ATP activity to reduce: Because Na  K  ATP