IL6 and type 2 diabetes related macrovascular.docVIP

 PAGE \* MERGEFORMAT 10 IL6 and type 2 diabetes related macrovascular [Keywords:] interleukin-6; 2 diabetes mellitus; Atherosclerosis; macrovascular complications in type 2 diabetes Diabetic atherosclerosis (AS) the incidence of non-diabetic patients than in age from 2 to 6 times higher, epidemiology shows that 85% of type 2 diabetes mellitus (T2DM) patients died of cardiovascular and other major vascular complications, which occurred early, rapid progression and poor prognosis, the exact mechanism remains unclear. In recent years, has been reported at home and abroad that T2DM is a sub-clinical inflammatory disease, inflammatory cytokine interleukin 6 (IL 6) and other macrovascular complications in T2DM played an important role in the (1,2). This paper further explore IL 6 in T2DM the role of major vascular disease and its clinical significance. 1 Materials and Methods 1.1 normal control subjects 30 patients, from healthy Xuanwu Hospital clinic, excluding diabetes, coronary heart disease and hypertension and other chronic diseases and acute infections and smoking, hyperlipidemia, overweight and obese and other patients, 12 male patients, 18 female, aged 35 to 74 (mean (60.07 + -9.29)) years old. 132 patients met the WHO diagnostic criteria of T2DM patients, from Xuanwu Hospital of the hospitalized patients, 72 male and female 60 cases, aged 30 87 (average (62.06 + -11.84)) old. by without macrovascular complications and AS combined risk factors (hyperlipidemia, obesity or overweight and high blood pressure) is divided into A group: T2DM without macrovascular disease group; B Group: T2DM with macrovascular disease risk factors in non-AS group; C group: T2DM with macrovascular disease are a risk factor for AS. group for age, sex was no significant difference. macrovascular selected must meet the following criteria at least one : electrocardiogram, coronary angiography, Holter monitoring or echocardiography confirmed the clinical coronary artery di