In patients with systemic lupus erythematosus CD62p expression.docVIP

 PAGE \* MERGEFORMAT 3 In patients with systemic lupus erythematosus CD62p expression [Abstract] Objective: To investigate the systemic lupus erythematosus (SLE) patients with platelet membrane surface expression of CD62p to understand the changes in platelet function in patients. Methods: Using fluorescent-labeled monoclonal antibodies and flow cytometry to measure the expression levels of SLE patients with CD62p using automatic blood cell analyzer for platelet count (BPC), was measured using automatic blood coagulation prothrombin time (PT ), partial thromboplastin time (APTT) and fibrinogen (Fg). Conclusion: SLE patients was significantly higher expression levels of CD62p, suggesting that a large number of platelet activation, involved in inflammation and thrombosis, in patients with platelet count and function of the body there is a double change. [Keywords:] systemic lupus erythematosus; platelet activation; CD62p; expression Systemic lupus erythematosus (SLE) is an involving multi-system, multi-organ autoimmune chronic inflammatory disease, blood system is often involved, with platelet changes, micro-thrombosis. In recent years, studies have shown that platelet activation and autoimmune disease-related, but on changes in platelet function in patients with SLE studies have reported fewer still. In this study, flow cytometry (FCM) in patients with SLE observed the expression of platelet membrane protein CD62p to further explore the functional status of platelets in the genesis and development of SLE may be the mechanism for clinical therapy. An object and methods 1.1 Object SLE group 28 cases are in line with the 1982 American Rheumatism Association (ARA) diagnostic criteria on the SLE. 1 male and female 27 cases; aged 18 to 69 years, mean 46 years of age; course of 2 months to 6 years; SLE DAI score [1] were more than 10 points, all patients with clinical activity. Control group, 28 cases of healthy controls, of whom 16 cases of female, male 12 cases,