In vitro donor heart preservation techniques Research.docVIP

 PAGE \* MERGEFORMAT 18 In vitro donor heart preservation techniques Research Author: Jian-Feng Zhang, Yong Cui Li, Black Dragon [Keywords:] Heart preservation solution; endothelial cell; endothelium-derived relaxing regulatory factor; endothelium-derived hyperpolarizing factor An overview of a heart preservation solution Heart preservation solution for heart transplantation for myocardial protection during cardiac ischemia in the liquid. Most of the existing heart preservation solution is based on protection of myocardial cells as the central link of the organ preservation solution designed to have achieved a better clinical results. At present on the cardiac preservation solution on myocardial cell protection mechanisms have been more clear, but the protective effect on coronary blood vessels is not yet very clear. Is now clear that the integrity of coronary endothelial cells to restore cardiac function plays a key role. Recent studies have shown that long-term heart transplant the first cause of death for cardiac allograft vasculopathy (Cardiac allograft vasculopathy, CAV) [1]. Cold preservation solution to prevent side-effects and the protection of coronary endothelial cell structure and function of a complete study of cardiac preservation solution on two important aspects. Currently the more common application of HTK solution (Histidine-Tryptophan-Ketoglutarate) and UW solution (University of Wisconsin solution), an intracellular fluid-type preservation solution. Celsior solution, an extracellular-type preservation solution. Present a variety of cardiac effects of preservation solution to save the study results are not consistent. Kajihara [2] study concluded that: UW solution is more beneficial than the Celsior prolonged organ preservation and preserving coronary endothelial function after 24h recovery. However, studies suggest that the use of Celsior in Heart Transplantation to save than any other liquid crystal and Han Xue preservation solution bet