Independent living on the dementia rat brain p38MAPK signal transduction pathway.docVIP

 PAGE \* MERGEFORMAT 10 Independent living on the dementia rat brain p38MAPK signal transduction pathway [Abstract] Objective To investigate the independent living of the Chinese Qufengchushi A dementia model rats induced by intracerebral injection of brain protection. Methods 30 male Wistar rats with intracranial injection of A protein in hippocampal CA1 area, were randomly divided into SM group , independent living group, western medicine group, sham operation group and model group, 6 in each group were treated with Salvia, independent living, indomethacin and saline. experimental animals were killed 4 w at the end, testing p38 MAPK, in rat brain expression. Results of each group after the experiment except the sham group, the value of the water maze test have different levels of change, p38 MAPK in the different groups of rats brain is different, Chinese live alone can inhibit the p38 MAPK in rats brain (P lt;0.05. Conclusion dementia live alone can improve learning and memory in rats and inhibit p38 MAPK in dementia model in rats brain. [Keywords:] Alzheimer’s disease, amyloid protein, p38 MAPK pathway Alzheimer’s disease (AD) is old and in early old age, irreversible, and progressive to the spirit of abnormal behavior-based brain degenerative diseases, can endanger the lives of patients with advanced, the incidence and mortality rates increased year by year . AD pathological mechanisms are not yet clear. In recent years, found that non-steroidal anti-inflammatory drugs for the treatment of this disease have a certain role, and thus make the hypothesis of immune and inflammatory diseases are concerned. The disease is dementia in a Chinese medicine, Chinese medicine and more that the five internal organs Deficiency-oriented, wet phlegm and blood stasis as the standard, study drug Heracleum Qufeng wins wet-based entry point for disease treatment, the use of non-steroidal anti-inflammatory drugs for the control of independent living in the inhibition