Injection of Pseudomonas aeruginosa pleural fluid of 42 cases the treatment of malignant pleural effusion.docVIP

 PAGE \* MERGEFORMAT 5 Injection of Pseudomonas aeruginosa pleural fluid of 42 cases the treatment of malignant pleural effusion January 2008 -2010 in June, we intrathoracic injection of Pseudomonas aeruginosa to the injection in the treatment of malignant pleural effusion in 42 cases are reported as follows: 1 Materials and Methods 1.1 Clinical data: 42 cases were confirmed by pathology or cytology of malignant pleural effusion caused by malignant tumors, 26 males, 16 females, aged 41-75 years, mean 61.5 years old. Including 28 cases of lung cancer , 6 cases of lung squamous cell carcinoma, 2 cases of small cell lung cancer, breast cancer, 3 cases of primary liver cancer in 1 case, 2 cases of pleural mesothelioma. All the patients had had no formal chemotherapy and intrapleural injection drug history, not during treatment with other biological agents. 1.2 delivery methods: 42 patients were in the B-targeting central venous catheters used under the ipsilateral thoracic cavity closed drainage, drainage of pleural effusion in a clean as possible, and by the B-and X-ray later confirmed, and then through the central slow intravenous catheter into the pleural cavity of 2% lidocaine injection 20ml and Pseudomonas aeruginosa (trade name: million Te Puan, Patel Beijing million biopharmaceutical company, approval number: Zhunzi S200430223ml. perfusion Close chest after drainage tube, and Zhu Huanzhe changing position several times to make extensive contacts with drug and chest the next day, open the chest drainage tube, usually 2 times a week, a total of 2 or 3 times. the blood before and after injection, blood inorganic elements, liver and kidney function, X ray and B-mode ultrasound before and after treatment of pleural effusion based primarily on changes in X ray and B-results. observed after injection in patients with body temperature, chest pain and so on. 1.3 Response Evaluation Criteria: the standards set by WHO [1], complete remission (CR