Intercellular adhesion molecule1 in cardiopulmonary bypass lung injury and the effect of the intervention effect Shenmai injection.docVIP

 PAGE \* MERGEFORMAT 2 Intercellular adhesion molecule1 in cardiopulmonary bypass lung injury and the effect of the intervention effect Shenmai injection Author: Wang Jun Wang Liangrong Huming Lun Chen Fei Miao Jian-Xia Lin Lina [Abstract] Objective: To observe the expression of intercellular adhesion molecule  1 (ICAM  1) lung injury during cardiopulmonary bypass the role of Shen Mai injection (SM) mechanism of lung protection. Methods: Cardiac valve replacement surgery 30 patients were randomly divided into control group and observation group, all 15 cases, the observation group during cardiopulmonary bypass (CPB) before transfer Shenmai injection 0.6 ml / kg by adding 250 ml normal saline intravenous drip injection is completed, the control group at the same time to 250 ml normal saline intravenously and the remaining two sets of the same methods to maintain anesthesia. Respectively, before induction of anesthesia (T0), CPB shut down after 0.5 hours (T1), 2 Xiaoshi (T2), 6 Xiaoshi (T3), 24 Xiao Shi (T4), taking the radial arterial blood-gas analysis, recording PO2, PCO2, FiO2 calculate alveolar - arterial oxygen difference [P (A  a) DO2] and respiratory index (RI), and specimens from measured serum intercellular adhesion molecule  1 (ICAM  1) the concentration of CPB at the same time records the time and the main artery occlusion time. Results: P (A  a) DO2, RI, ICAM  1 was significantly higher after the shutdown during cardiopulmonary bypass (P