Interleukin-18 in the role and significance of coronary heart disease in.docVIP

 PAGE \* MERGEFORMAT 17 Interleukin-18 in the role and significance of coronary heart disease in Abstract Acute coronary syndrome (ACS) and coronary atherosclerotic plaque instability has a direct relationship. In recent years, that the inflammatory response and plaque occurrence, the evolution of closely related. CRP may be atherosclerotic lesion progression of the disease as reflected in the evolution of a sign. This article will CRP on the predictive value of cardiovascular events in ACS, as well as make a meaningful analysis. Keywords: Interleukin-coronary heart disease Inflammatory reaction in atherosclerotic disease formation, development and the incidence of ischemic heart disease development process, plays an important role. Among them, some of the role of inflammatory mediators is very important. Interleukin-18 is more emphasis in recent years, a class of inflammatory mediators, in respect of its role and significance of coronary heart disease in a comprehensive overview. 1 IL-18 source, structure, and function of 1991 was extract from mouse liver was isolated to a TH1 cells can induce IFN-r of the molecular weight of about 18KD protein was named as IFN-r-inducing factor (IGIF) [1]. After, VSHER such as CDNA library was screened from rat to human IGIF gene expression in E. coli, its sequence and biological function of cytokines with known differences in 1996 will be named interleukin-18. 1.1 sources in a variety of organs, tissues and cells can be detected in IL-18mRNA, such as the thymus, liver, spleen. Kidney, pancreas, KUFFER’s cells and activated macrophages. By RT-PCR has been found 40 different human cell lines expressing IL - 18mRNA, while monocyte-macrophage cells, is highly expressed in T, B cells, little or no expression shows that IL-18 primarily by mononuclear macrophages, has now moved from human umbilical cord blood CD34 progenitor cells was amplified by the DC and the mouse and human bone ma