Irbesartan on the isolated rat heart ischemia-reperfusion apoptosis.docVIP

 PAGE \* MERGEFORMAT 9 Irbesartan on the isolated rat heart ischemia-reperfusion apoptosis [Abstract] Objective To observe the???isolated rat myocardial ischemia reperfusion apoptosis, and of its mechanisms. Methods Langendorff device uses a complete halt production of irrigation method of reperfusion for myocardial ischemia in isolated rat reperfusion injury model. the 48 SD rats were randomly divided into 3 groups: control group (KH buffer continuously perfused 110 min, ischemia-reperfusion group (KH buffer infusion to stabilize the targets, about 20 min, Stop irrigation 30 min, reperfusion 60 min, irbesartan group (perfusion with the ischemia-reperfusion group, but the KH buffer ?????? 10-6 mol / L. (1) take n = 8 only myocardial tissue SOD activity, MDA content. (2 each remaining eight: the control group continued to KH buffer perfused 170 min. ischemia-reperfusion group and the irbesartan group to the continuous perfusion stop filling the indicators stabilized 30 min, reperfusion 120 min. observation of apoptosis. Results (1 ischemia-reperfusion group MDA content in myocardial tissue was significantly higher than the control group (P lt;0.01 The total superoxide dismutase activity was significantly lower than the control group (P lt;0.01. (2 irbesartan group compared with the ischemia reperfusion group, the total superoxide dismutase activity was significantly increased (P lt;0.01, MDA MDA significantly decreased (P lt;0.01. (3 ischemia-reperfusion group were significantly higher apoptotic index (P lt;0.01. (4 irbesartan group cell apoptosis and ischemia-reperfusion group were significantly lower (P lt;0.01. Conclusion Irbesartan inhibit the myocardial ischemia-reperfusion injury in the role of myocardial apoptosis. which may scavenge oxygen free radicals and irbesartan to reduce lipid peroxidation. [Keywords:] reperfusion injury apoptosis Recent studies have shown that apoptosis of myocardial ischemia-reperfusion injury is one important part of