Ischemic postconditioning on coronary heart disease in patients with limb ischemia of vascular endothelial function.docVIP

 PAGE \* MERGEFORMAT 12 Ischemic postconditioning on coronary heart disease in patients with limb ischemia of vascular endothelial function Of: Ma Xiaojing Qi Chunlei Zhang Xinghua Ma Hongjun Li Chunmei Shao J H. [Abstract] Objective To observe the ischemia and reperfusion after ischemia at different times given to adapt, on endothelial function in patients with coronary heart disease in rats. Methods 54 patients with coronary heart disease were randomly divided into 3 groups, ischemia reperfusion group, after a delay after the group and to adapt to meet the group. established model of limb ischemia, reperfusion at different times (1 min and 1 min after internal) were given after a delay after the group and to adapt to meet the group postconditioning intervention, through ultrasonic testing brachial artery flow-mediated dilation (FMD), observed before and after ischemia and reperfusion reactive hyperemia blood vessel diameter. Results ischemia-reperfusion group FMD was significantly decreased after reperfusion (P lt;0.05), 1 min reperfusion given within obviously postconditioning protective effect of vascular endothelial function, and ischemic reperfusion group, after the adaptation was significantly improved FMD (6.70 + -2.36 vs 3.05 + -0.91, P lt;0.05), after the adaptation was delayed the loss of protective effect of endothelial function (3.17 + -1.04 vs 3.05 + -0.91, Pgt; 0.05). conclusions given within 1 min reperfusion after ischemia adaptation can improve endothelial function, but delayed protective effect disappeared after the meet. [Keywords:] Coronary heart disease; reperfusion injury; ischemic postconditioning; vascular endothelial; delayed postconditioning [Abstract] Objective To explore the effect of ischemia preconditioning (IPC) and postconditioning on emergency percutaneous coronary intervention (PCI) in elderly patients with acute myocardial infarction (AMI). Methods 106 elderly patients with AMI who received PCI within 12 h were se