Kinship between the HLA haploidentical peripheral blood stem cell transplantation for acute leukemia.docVIP

 PAGE \* MERGEFORMAT 13 Kinship between the HLA haploidentical peripheral blood stem cell transplantation for acute leukemia Author: Tony Li, Zhi-Wei Wang, Guo, Wang Jun, Hou Lanfen, Sun Yu, Guo Mou, Li Wenjing [Abstract] Objective To investigate the HLA haploidentical peripheral blood stem cell transplantation (PBSCT) for acute leukemia efficacy and safety. Method 4 cases of acute leukemia patients undergoing HLA-mismatched PBSCT, including two cases of acute lymphoblastic leukemia, acute non-lymphocytic leukemia  M4b 1 Li, M4EO 1 cases, transplants were in complete remission. HLA typing of 1,2-sub-loci in 1 case, three sub-loci in 2 cases. Or by total body irradiation conditioning regimen Busulfan amines, cytarabine, cyclophosphamide, CCNU composition. Graft-versus-host disease (GVHD) prevention of use of cyclosporin A, methotrexate, mycophenolate mofetil, anti-thymocyte globulin quadruple. The results of the transplanting process in patients, 4 patients have received hematopoietic reconstruction and achieved complete donor implant. Ⅰ degree in 3 cases of acute GVHD, 1 patients had grade Ⅱ acute GVHD. 1 case complicated by cytomegalovirus interstitial pneumonia, two cases of fungal pneumonia. So far two cases of patients were disease-free survival of 30 months and 15 months, 1 case is currently in April after transplantation, 1 died. Conclusions HLA haploidentical PB [Keywords:] leukemia; HLA; haploidentical; stem cell transplantation; graft-versus-host disease Abstract: Objective To explore the efficiency and safety of HLA partially mismatched peripheral blood stem cell transplantation (PBSCT) for treatment of acute leukemia.Methods Four patients with acute leukemia in complete remission, including two with acute lymphocytic leukemia and two with acute non  lymphocytic leukemia  M4, were treated by HLA partially mismatched PBSCT. Of the four patients, one was HLA1 locus mismatched, one HLA2 locus mismatched and the other two with HLA3 locus misma