Klebsiella pneumoniae β lactamases and associated resistance phenotype analysis.docVIP

 PAGE \* MERGEFORMAT 13 Klebsiella pneumoniae β lactamases and associated resistance phenotype analysis [Abstract] Objective: To study the Respiratory Klebsiella pneumoniae 14 kinds of commonly used antibiotics and their producing extended spectrum β  lactamases (ESBLs) detection rate of strains. Methods: Respiratory isolated from clinical Klebsiella pneumoniae, with K  B disc diffusion method, double disk synergy test and the confirmatory test paper screening and confirmation of ESBLs producing strains. The results: 3 a of Respiratory Klebsiella pneumoniae producing ESBLs overall detection rate was 36.7% (94/256), ESBLs producing strains are highly sensitive to imipenem (100%), to ampicillin, cefazolin , cefotaxime, ceftriaxone, gentamicin, ciprofloxacin have very high resistance (resistance rate of “80%), higher than the group did not produce ESBLs, the difference was significant (P lt;0.005). Conclusion: Respiratory Klebsiella pneumoniae strains producing ESBLs in clinical isolates of the high rate of multiple antibiotics with high resistance, imipenem treatment for ESBLs-producing Klebsiella pneumoniae infection in drug of choice. [Keywords:] Klebsiella pneumoniae; β  lactamase; resistance; Respiratory Plasmid-mediated extended spectrum β  lactamases (ESBLs) in the generation and dissemination of Gram-negative bacilli to β  lactam antibiotics resistant to one of the important reasons [1]. Klebsiella pneumoniae is the most common ESBLs producing strains [2], has become an important pathogen of nosocomial infection can cause a serious hospital infection outbreaks and the spread of resistant strains outside the hospital [3]. In particular, plasmid-mediated ESBLs broad spectrum of its substrate, spread fast and attracted wide attention. We are from January 2003 to December 2005 our hospital Respiratory Klebsiella pneumoniae isolates were determined and the antibiotic sensitivity of strains producing ESBLs were detected, are repor