Kudzu extract on osteoporosis induced by dexamethasone protection model.docVIP

 PAGE \* MERGEFORMAT 11 Kudzu extract on osteoporosis induced by dexamethasone protection model Study: Song Weiguo Sun Fu Jun Wang Changchun Interfere [Abstract] Objective To observe the kudzu extract on dexamethasone induced rat model of osteoporosis to explain its mechanism of action of osteoporosis treatment for pharmacodynamic basis for clinical application. Methods Wistar rats were balanced according to body weight randomly divided into control group, model control group, XLGB positive drug (270 mg / kg group and kudzu extract 200,100,50 mg / kg dose group, 12 in each group. In addition to the control group after group In addition, other groups 2 times a week (Mondays, Thursdays intramuscular injection of dexamethasone phosphate 1.5 mg / kg, control group injected with the same volume of saline, intragastric administration while subjects liquid. continuous administration of 6 months after the general condition of rats to determine the quality of the volume ratio of femur, femoral mechanical properties were measured. kudzu extract significantly improved the results of modeling the general situation in rats, rats increased weight, increased uterine and ovarian factor. three treatment group were significantly increased bone resistance to external force, significantly improve the performance of femoral resistance force. collecting said rats femur dry weight and ash weight to calculate wet weight, dry weight, ash weight and volume ratio, suggesting that different treatment group to improve the modeling of different degrees of osteoporosis caused by the performance of the three dose groups were statistically different (P lt;0.01. Conclusion Dexamethasone kudzu extract on rat model of osteoporosis induced by treatment with a clear effect. [Keywords:] kudzu extract, osteoporosis, rat, biomechanics For the legume Pueraria lobata pueraria lobata (Willd.) ohwi or Gan lobata (kudzu pueraria thomsonii Benth.’s Roots, only contained in the lt;lt;Shen Nong’s