Lamivudine treatment of decompensated cirrhosis Efficacy of hepatitis B.docVIP

 PAGE \* MERGEFORMAT 3 Lamivudine treatment of decompensated cirrhosis Efficacy of hepatitis B Author: Wei Junfeng Zhang Guoying Zhang Yun Yang catkins [Abstract] Objective: To observe the period of lamivudine treatment of hepatitis B patients with decompensated cirrhosis. Methods: 40 cases of hepatitis B patients with decompensated cirrhosis were randomly divided into treatment group and control group, treatment group were given oral lamivudine 100 mg / d, 52 W, the control group without antiviral drugs. In the before and after treatment were used to detect liver function, HBV serologic markers, HBV-DNA, endotoxin (ET), IL-6 and TNF-α levels. Results: Lamivudine can inhibit viral replication in patients with active cirrhosis of the liver and improve liver function, lower ET, IL-6 and TNF-α level, alleviate the condition. Conclusion: Lamivudine for the treatment of decompensated hepatitis B cirrhosis. [Keywords:] Lamivudine; hepatitis B; cirrhosis; decompensation With chronic hepatitis B liver cirrhosis patients, especially patients with decompensation, there is active viral replication, the mortality was significantly higher than in patients without viral replication. Therefore, people try to inhibit or clear the viral replication and chronic hepatitis B patients with cirrhosis of the liver improved. α -interferon (INF-α ) and lamivudine is now recognized as an effective anti-HBV drugs. However, INF-α therapy in patients with cirrhosis there may be some risk, therefore, generally not in favor of his for the treatment of patients with decompensated cirrhosis. It was reported that lamivudine on HBV related decompensated liver cirrhosis in patients with better efficacy and safety [1,2]. Undergraduate on the basis of the combined treatment with decompensated liver cirrhosis treated with lamivudine achieve better efficacy, reported as follows. 1 Data and methods 1.1 Objects and Methods 1.1.1 Object: To observe the object for the 2001 ~ 2006 Changzhi peace