Langerhans cells and contact hypersensitivity.docVIP

 PAGE \* MERGEFORMAT 7 Langerhans cells and contact hypersensitivity Abstract: Langerhans cells as the skin to the main antigen-presenting cells is receiving increasing attention, semi-antigen can induce Langerhans cell migration, differentiation, maturation, Langerhans cells through the expression of cytokine receptors, neurotransmitter receptors, adhesion molecules and inducible nitric oxide synthesis of enzymes involved in contact hypersensitivity. External factors can damage or alter the Langerhans cell surface molecule expression, influence the contact hypersensitivity induced. Contact hypersensitivity (cHS) is a cD8 T cells (cD8 tc)-mediated sensitization of the skin response to hapten to produce γ -interferon (iFN-γ ) in cD8 Tc and produce interleukin -4 / Interleukin -10 (iL-4/IL-10) of cD4 Tc (th2) controls the cHS the severity and duration [1]. Langerhans cell (lC) is derived from bone marrow and spleen dendritic cells, mainly present in the epidermis, is the main antigen-presenting cells in the epidermis. Hapten in the epidermis after exposure, lC hapten capture processing, semi-lC surface antigen and immune response of hLA-DR antigen after the formation of a complete antigen complex, lC carry the complete antigen reached the lymph node, the antigen was handed t cells, induced cHS place. Studies have shown that the density of skin in the lC impact cHS result of natural or man-caused loss of lC-induced cHS will not be happening. As the hamster (hamster) cheek pouch epithelium lack of lC, coated on its surface after contact with allergens lead to non-specific reaction occurred [2]. In recent years, many scholars lC in cHS the receptor expression, cytokine secretion, neurohormonal regulation, external factors such as ultraviolet radiation (uVR) the impact of its function has done numerous studies. This paper, to make a review. I. Langerhans cell migration, differentiation, mature After the initial contact with hapten, the epidermis of the lC u