Leech Dragon capsule deposition promoting blood circulation on acute cerebral infarction ischemia - reperfusion neuronal apoptosis and related gene expression.docVIP

 PAGE \* MERGEFORMAT 14 Leech Dragon capsule deposition promoting blood circulation on acute cerebral infarction ischemia / reperfusion neuronal apoptosis and related gene expression [Abstract] Objective vermiculite Dragon capsule deposition promoting blood circulation on acute hemispheric ischemic / reperfusion neuronal apoptosis and related gene expression. Methods lines established by tying focal cerebral ischemia and reperfusion injury model, 40 male SD rats were randomly divided into two groups (promoting blood circulation silt vermiculite Dragon capsules) 10 patients in the control group (step Naoxintong) in 10 cases, 10 cases of the model group and sham operation group of 10 patients, medication 7 d, TUNEL method and the application of immunohistochemistry to detect the apoptotic cells in brain tissue and distribution of bcl-2, Caspase-3 protein expression. Results confirmed that acute cerebral ischemia-reperfusion injury apoptosis The existence of the number of neuronal apoptosis in the model group were significantly higher than sham operation group (P lt;0.01), promoting blood circulation silt vermiculite group and the Dragon step Naoxintong drug intervention group compared with the model group significantly lower apoptotic index ( P lt;0.01), but the vermiculite group and the Dragon, promoting blood circulation silt step Naoxintong drug intervention was no significant difference between the two groups (Pgt; 0.05). model group of brain cells in bc1-2 and Caspase-3 gene expression were significantly compared with the sham group (P lt;0.01), compared with model group, vermiculite group and the dragon promoting blood circulation and deposition was significantly increased Naoxintong bc1-2 gene expression (P lt;0.01), significantly inhibited the expression of Caspase-3 gene (P lt;0.01), promoting blood circulation silt vermiculite group and the Dragon step Naoxintong drug intervention was no significant difference between groups (Pgt; 0.05). Conclusion l