Linezolid against vancomycin-sensitive and-resistant enterococci of the antibacterial activity of feces.docVIP

 PAGE \* MERGEFORMAT 7 Linezolid against vancomycin-sensitive and-resistant enterococci of the antibacterial activity of feces Authors: Yun Li Zheng Bo Giuseppe Mrs Nan Xue Feng Wei Zhong Wang Shan [Abstract] Objective To evaluate the linezolid against clinical isolates of vancomycin-sensitive and-resistant enterococci in vitro antibacterial activity of feces. Multi-PCR method of identification of vancomycin-resistant Enterococcus feces genetic types, Plate two-fold dilution of 11 linezolid MIC values of antimicrobial agents. The results of 75 clinical isolates of vancomycin-resistant enterococci feces were carrying vanA gene. Feces sensitive and vancomycin-resistant enterococci were sensitive to the linezolid, MIC range of 1 ~ 2mg / L. And erythromycin, ampicillin, levofloxacin, and rifampin compared with vancomycin-sensitive and-resistant enterococci feces resistant rates were above 80%. Vancomycin-sensitive enterococci feces of high-level gentamicin and high concentrations of streptomycin, tetracycline and chloramphenicol resistance rates were 80.2%, 13.9%, 38.6% and 37.6%; vancomycin-resistant feces Enterococci on these four kinds of drug resistance rates were 64.5%, 8.0%, 18.5% and 5.3%. Conclusion linezolid against clinical isolates in China and drug-resistant vancomycin-sensitive enterococci feces all have excellent in vitro antibacterial activity. [Keywords:] linezolid; vancomycin-resistant; feces Enterococcus; vanA ABSTRACT Objective To investigate in vitro antibacterial activity of linezolid against vancomycin  susceptible Enterococcus faecium (VSE) and vancomycin  resistant Enterococcus faecium (VRE). Methods The van genes were detected by multiplex PCR and MICs of linezolid and other 10 agents were determined by the two  fold agar dilution method. Result 75 VRE isolates were all carried vanA. All VSE and VRE isolates were susceptible to linezolid (MIC range 1 ~ 2mg / L), more than 80% of VSE and VRE isolates were resistant to erythromycin,