Ling San Qinlian surgery Acute Toxicity Test.docVIP

 PAGE \* MERGEFORMAT 6 Ling San Qinlian surgery Acute Toxicity Test [Abstract] Objective Qinlian Ling scattered in mice fed patients with acute toxicity test, to observe the safety, provide a basis for clinical research. Methods Qinlian surgery Ling San maximum concentration, the maximum volume on the intragastric administration were determined day administration of its maximum capacity. The results in mice administered the largest amount of day 2.08g, equivalent to 130 adult clinical daily dose times. Conclusion Ling San Qinlian surgery more safe for clinical research trial. [Keywords:] Ling San Qinlian surgery; acute toxicity; mice; experimental study Milk infant diarrhea is a common chronic disease, if not controlled in time, may result in children with developmental disorders, Pediatrics Department of Health has listed it as an important “four disease control” one. Of which the most common type of heat, and the course is long delay, treatment difficult. our group based on clinical experience, that “infants and sick tune parent” to baicalin, berberine, such as the main drug composition “Qinlian surgery Ling San” treatment of the disease, and achieved satisfactory results [1]. In this study, mice by gavage, observation of surgery Ling San Qinlian acute toxicity, to evaluate the safety, provide the basis for clinical research. 1 Materials 1.1 Drug Qinlian surgery Ling San (batch number from Zhongjing States Institute of Medicine of Chinese medicine, 20 g / bag, the daily recommended dosage is 40 g. of clinical experiments prior to the preparation of this product in mice fed the maximum available concentration of suspension, equivalent to 1.3 g per ml of crude drug. 1.2 Animal KM mice, one, 7 weeks old, weighing 18 ~ 22 g, ♀ ♂ half and half. Nanyang provide farm animals. 2 Methods and Results 2.1 Pre-experiment [2] before conducting a formal experiment, we first made a preliminary experiment in order to provide the basis for th