Lhasa district anti-tuberculosis drugs on liver function and impact analysis.docVIP

 PAGE \* MERGEFORMAT 3 Lhasa district anti-tuberculosis drugs on liver function and impact analysis [Abstract] Objective To analyze the environmental conditions at high altitude, the anti-tuberculosis drugs on liver function, provide a scientific basis for rational therapy. Methods Hitachi 7180 automatic biochemical analyzer in 86 cases of pulmonary tuberculosis before and after anti-tuberculosis treatment in patients with liver function test. Results throughout the abnormal rate of liver function 40.7% (35/86), 28 cases of liver protection in strengthening the case to anti-tuberculosis treatment, 20 days to 3 months, liver function returned to normal, to achieve therapeutic effect; 6 cases out anti-TB drugs in whole or in part of the liver protection therapy, when normal liver function continued after anti-TB treatment, no further liver function abnormalities; 1 cases because of their age too, all out anti-TB drugs after 3 months, liver function did not return to normal; 94.4% of patients with abnormal liver function occurred in the medication within 2 months after. Conclusion The anti-TB treatment in patients with pulmonary tuberculosis at the same time, should closely monitor liver function, early prevention and detection, treatment of drug-induced liver injury. [Keywords:] anti-TB drugs; tuberculosis; liver function; drug-induced liver With the continuous destruction of environmental conditions, the global incidence of TB has serious rebound trend, the application of anti-tuberculosis drugs also will increase [1]. In the plateau region due to many factors, the incidence of tuberculosis has been among the first in the country, due to hypoxic environmental conditions on the human body produces many negative factors, and sustained multiple-drug combination treatment longer than others. Anti-tuberculosis drug-induced liver damage leading to failure of one of the main TB treatment, how to address the treatment of liver damage caused by the treatment of tuberc