MAPK pathway and liver fibrosis.doc

 PAGE \* MERGEFORMAT 14 MAPK pathway and liver fibrosis Wang Gang, Cun-Liang Deng [Keywords:] liver fibrosis; cirrhosis; hepatic stellate cell; mitogen-activated protein kinase The mechanism of liver fibrosis is a complex process, many factors (external stimuli, UV, hypoxia caused by the body such as the release of inflammatory factors (TNF-a, IL-6, IL-1, PDGF, etc. To activate the various fibers of the pathway (TGF-1, CTGF, MAPK, etc.) of the hepatic stellate cell activation, increased extracellular matrix synthesis and secretion, and reduced its degradation, leading to ECM accumulation and hepatic fibrosis and even cirrhosis. mitogen activated protein kinase (mitogen activated protein kinase, MAPK) signal in all eukaryotic cells will be delivered to cells from the primary receptor signaling pathway. In this paper, MAPK pathway and liver fibrosis are reviewed. 1 mitogen-activated protein kinase family MAPK is the cytoplasm of a class of highly conserved serine protein kinase [1], mammalian cells, including MAPK extracellular signal-regulated kinase (extracellular signal regulated protein kinase, ERK), C-Jun N-terminal kinase (C-Jun amino -terminal kinase, JNK), P38MAPK and ERK5/BMK1 (big MAPK1) four sub-families. eukaryotic cells have identified four MAPK signaling pathway, that is, extracellular signal-regulated kinase 1 / 2 (ERK1 / 2) pathway , c-Jun N-terminal kinase (JNK) pathway, p38MAPK pathway and extracellular signal-regulated kinase 5 (BMK1/ERK5) pathway [2]. mediated cell growth, development, proliferation, differentiation, aging and death of the entire process etc. physiological processes. MAPK family, including sequential activation cascade MAPKKK (MAPK Kinase Kinase), MAPKK (MAPK Kinase) and MAPK.MAPK / ERK signaling pathway play a role in the H-ras MAPKKKK expression is always at a high level, A-raf (MAPKKK), MEK2 (MAPKK), ERK1 (MAPK) kinase and other downstream transcription was also significantly increased, and the corresponding inh