Maternal serum hepatitis B virus markers and clinical significance of determining HBVDNA.doc

 PAGE \* MERGEFORMAT 7 Maternal serum hepatitis B virus markers and clinical significance of determining HBVDNA [Abstract] Objective To investigate maternal hepatitis B virus (HBV) infection in serum virus markers (HBV-M) combined with the relationship between HBV DNA to guide the mother to child transmission blocking immune intervention. Methods ELISA detection of hepatitis B virus serological markers material (HBsAg, HBsAb HBeAg HBeAb HBcAb), real-time fluorescence quantitative PCR (FQ-PCR) test on 268 pregnant women infected with HBV DNA levels in serum. Results HBsAg positive HBV DNA positive group was 49.4% (83 / 168), HBsAg HBV DNA positive rate was negative 11.10% (11/100), both significantly different (P lt;0.01), but HBsAg (-) group the total number of HBV DNA positive in 11.7% (11/94). Conclusion Clinical only According to HBV serum markers to determine the antigen-antibody detection of infectious patients is not comprehensive, and should pay attention to low levels of HBsAg-negative patients with HBV replication, combined with the detection of HBV DNA synthesis to determine the results in order to avoid intrauterine HBV infection. vaccinated blocking HBV mother to child transmission. [Keywords:] pregnant women; hepatitis B virus serum markers; HBV DNA; mother to child transmission Hepatitis B virus (HBV) is a common infectious disease, serious harm to human health. China is a high incidence of hepatitis B, hepatitis B surface antigen carriers as high as 10% ~ 15%. HBV infection not only resulted in a large number of HBV chronic carrier also contributed an important factor in infant infection. research shows that the main carriers of HBsAg from mother to child transmission [1]. mother to child transmission is one important way to the spread of HBV [2]. on the HBsAg-positive pregnant women and their unborn child Prevention has become the urgent problems of medical workers. We found 268 cases of pregnant women there is a pregnancy test HBV infe