MCP1 gene A2518G polymorphism and unstable angina pectoris preliminary analysis of the relationship between.doc

 PAGE \* MERGEFORMAT 13 MCP1 gene A2518G polymorphism and unstable angina pectoris preliminary analysis of the relationship between On: Normal dry Wei, Guo-Ping, Qichuan Ping, Gao Lei, Qi Meng, Shen Dandan, Qian Zhihong, Xu United Red [Abstract] Objective: To explore the southern Chinese Han population of monocyte chemoattractant protein 1 (MCP 1 gene promoter A 2518G single nucleotide polymorphism and unstable angina pectoris (UAP relevance. Methods: case-control study, selected patients with clinically diagnosed 172 cases of UAP for the cases and confirmed by coronary angiography in 156 patients without coronary artery lesions for the control group. using the polymerase chain reaction and restriction fragment length polymorphism (PCR RFLP of the MCP 1 gene polymorphism A 2518G-line testing, and statistics of the genotype and allele frequency distribution. Results: Compared with the control group, UAP group of AA, AG and GG genotype frequencies did not differ statistical significance (P values #8203;#8203;were 0.067,0.825 and 0.281.G allele frequencies UAP group and control group were 54.36% and 61.22%, no significant difference between the two groups (P = 0.069. on a number of related Factors Multiple Logistic regression analysis showed that the line, MCP 1 gene A 2518G SNP and no correlation between the incidence of UAP (Pgt; 0.05. Conclusion: In Chinese Han population in Southern China, MCP 1 gene A 2518G mononuclear nucleotide polymorphism and UAP was no significant correlation. [Keywords:] unstable angina, monocyte chemoattractant protein 1, single nucleotide polymorphism [Abstract] Objective: To investigate the possible association between the monocyte chemoattractant protein 1 (MCP 1) gene A 2518G single nucleotide polymorphism (SNPs) in the promoter region with unstable angina pectoris (UAP) in Chinese Han population of Sunan region. Methods: This study was conducted with a case control design including 172 patients with UAP (UAP group) and