Mechanism of chronic osteomyelitis of new therapies.doc

 PAGE \* MERGEFORMAT 8 Mechanism of chronic osteomyelitis of new therapies [Keywords:] chronic osteomyelitis Chronic osteomyelitis caused by pathogens of a variety of reasons the periosteum, bone, marrow and soft tissue invasion and destruction made. With the CT, MRI and ultrasound of the popularity of the early detection of acute suppurative osteomyelitis of the disease. In CT , color Doppler ultrasound guided abscess puncture etiology check, puncture and drainage treatment of acute suppurative osteomyelitis of the early diagnosis greatly improve the accuracy and efficacy. But of chronic osteomyelitis is still hot orthopedic diseases. This paper will focus on infection control, debridement, defects of three links, the new treatment of chronic osteomyelitis mechanism analysis. 1 Infection Control 1.1 pathogens unreasonable application of antibiotics in recent years, the types of pathogens of chronic osteomyelitis change, resulting in bacterial mutation, bacterial resistance. Currently find, Tong Lvse Pseudomonas infection rate rose from No. 3 to No. 2, that bacteria infection decreased significantly increased Gram-negative bacteria infection, endogenous “normal flora” and the surrounding environment “opportunistic pathogen” has become suppurative osteomyelitis of the main pathogenic factors. recently discovered “ L “-type of bacteria cell walls of bacteria are sensitive to some or all loss arising from the variation of wall strain, with a reduction of reciprocating the biochemical characteristics of atavistic. When patients decreased resistance, or destroy the cell wall decreased the concentration of antibiotics in the bone marrow cavity, it can return progenitor as Staphylococcus aureus, the product of rapid-inflammatory bone marrow cavity filled Haversian canal, oppression nourishing capillaries, venous return to the small barrier, giving rise to the normal metabolism of bone tissue, leading to osteoclast and osteoblast cells, over-activity the de