Matrine on acute myocardial ischemia in rats hemodynamics.doc

 PAGE \* MERGEFORMAT 10 Matrine on acute myocardial ischemia in rats hemodynamics Of: Nieli Hong, Zhao Ruining, Ding Juan, Peng Tao, Zhou Yongzhong, Zhou Xu [Abstract] Objective matrine on acute myocardial ischemia in rats hemodynamics. Methods SD rats were randomly divided into 8 groups: control group, sham operation group, model group, SM group, nitroglycerin group matrine 2.5,5,10 mg / kg dose group. application of the left anterior descending coronary artery (LAD) ligation model of acute myocardial ischemia in rat was recorded before ligation, after ligation of the left in rats 5,15,30 and 60min ventricular systolic pressure (LVSP), left ventricular diastolic terminal (LVEDP), left ventricular pressure maximal rate of rise (+ dp / dtmax) and decreased the maximum rate of left ventricular pressure (-dp/dtmax) were measured. Results Compared with control group and the sham group, the left anterior descending coronary artery ligation 5,15,30,60 min, model group, LVSP, + dp / dtmax, -dp/dtmax significantly lower (P lt;0.05 or P lt;0.01), LVEDP increased significantly (P lt;0.01). Compared with model group, the left anterior descending coronary artery ligation 5,15,30,60 min, intravenous injection of matrine 2.5,5 and 10mg/kg in rats can be LVSP, + dp / dtmax, -dp/dtmax significantly higher (P lt;0.05 or P lt;0.01), LVEDP was significantly lower (P lt;0.05 or P lt;0.01). The role of the left anterior descending coronary artery ligation 15,30 min most Obviously, and with the dose increased, prolonged drug action. Conclusion Intravenous matrine in acute myocardial ischemia may improve cardiac function in rats. [Keywords:] matrine, hemodynamics, acute myocardial ischemia, rat Abstract: Objective To study the effects of matrine on the hemodynamics in Rats of Acute Myocardial Ischemic Injury. Methods Sprague-Dawley rats were divided into eight groups, ie, control, sham operation, AMI, Danshen + AMI, nitroglycerin + AMI, AMI + MT2.5mg/kg, 5mg/kg, or 10mg/k