Medical prevention and treatment of hypertension in experimental animal model of left ventricular hypertrophy Review.doc

 PAGE \* MERGEFORMAT 20 Medical prevention and treatment of hypertension in experimental animal model of left ventricular hypertrophy Review [Keywords:] Chinese medicine Review of animal models of hypertensive left ventricular hypertrophy In recent years, Chinese medicine prevention of left ventricular hypertrophy (LVH) in the literature gradually increased from the original simple clinical observation of Chinese medicine gradually to the experimental study and mechanism of micro-deepening. LVH with the prevention and treatment of Traditional Chinese Medicine to carry out experimental studies, relevant animal model of LVH increasing application and research, many scholars starting from different pathological mechanisms, copy a variety of animal models of hypertensive LVH. The author is the current prevention and treatment of Chinese medicine commonly used animal model of LVH and problems of the type to make a review. 1 Prevention of left ventricular hypertrophy in medicine commonly used animal model of type 1.1 spontaneously hypertensive rats Spontaneously hypertensive rats (SHR) is more similar to human essential hypertension in genetic rat model appeared soon after birth blood pressure, 12 to 16 weeks, rats with normal blood pressure compared to the same age there was a significant differences. SHR left ventricular mass and left ventricular mass index, cardiomyocyte size and diameters in early hypertension (6 weeks) no significant change, 7 to 8 weeks of age on left ventricular hypertrophy occur gradually, 14 weeks a significant increase in 24 weeks is more significant increase in [1]. Some scholars have used the role of complement Guifu Bawei Wan Yin Yiyang early intervention therapy can correct high blood pressure, thus suggest may be important in SHR model of yin and yang. but the pathological changes The process is complex, the above conclusions are further experimental evidence of the lack of support [2]. present study shows that a variet