Mechanical properties of articular chondrocytes Recent Research.docVIP

 PAGE \* MERGEFORMAT 32 Mechanical properties of articular chondrocytes Recent Research Keywords: mechanical properties of articular chondrocytes Recent Research The mechanical properties of articular chondrocytes affecting the joint health and function of important factors. On the mechanical properties of chondrocytes in-depth study will help to understand the cartilage cells in the normal and pathological conditions of the regulation, further cartilage repair provide a new direction. 1 Introduction Articular cartilage cells through biological, mechanical and physical and chemical interactions in the cartilage extracellular matrix in order to perceive their mechanical environment. Extracellular matrix components, including collagen (mainly type Ⅱ collagen), and proteoglycan. Collagen fibers form a dense cross-network to provide the essential tension and shear stress. Proteoglycan containing keratan sulfate and chondroitin sulfate glycosaminoglycan chains, its rich in negatively charged carboxyl and sulfate groups. The negative charge generated by mutually exclusive roles and infiltration pressure gradient led to the emergence of expansion within the organization. This expansion of the hydration pressure affect the organization and the local physical environment of cartilage cells to adapt to the stress load or deformation. Articular cartilage matrix rich in collagen type Ⅵ weeks and high concentration of proteoglycan. Cell weeks through a combination of matrix proteins in the matrix cell surface receptors and cartilage cell interactions. Cartilage cells and this layer of substrate by most scholars named Chondron. With regard to the function of this unique structural unit is still not clear, some scholars think that Chondron can be used as mechanical transduction devices, their weeks through the cell matrix type Ⅵ collagen and cell surface interaction of a number of components into the mechanical signal transducti