Mechanical stretch stress on bone cells research.doc

 PAGE \* MERGEFORMAT 22 Mechanical stretch stress on bone cells research Authors: Li Run-ray, Shao Fan, Wei-fat Keywords: mechanical stretch The normal absorption and growth of bone in a continuous process of reconstruction, osteoblasts and osteoclasts to maintain a dynamic balance of physical activity, machinery and mechanical stimulation is an essential requirement. A large number of studies have shown that: Mechanical low mechanical stress, such as when weight loss and long-term bed space, physically braking may all lead to bone mineral density, bone calcium content, bone matrix proteins, bone formation rate reduced; and post-menopausal women with the appropriate activities, exercise, increases bone load can reduce the incidence of osteoporosis. Mechanical environment in vivo complex, and in vitro experiments can be designed to load a specific way to control a variety of variables (different types of mechanics, size, frequency, time, and cells of different species, etc.), observe the cells respond to mechanical stimuli . In vivo experiments and clinical applications, find the appropriate stretch stress in the fracture repair, orthodontic tooth movement, as well as distraction osteogenesis (the correction of mandibular hypoplasia, bone defect restoration, limb lengthening), etc., by itself can stimulate bone tissue growth and reconstruction. Osteoblasts is an important feelings and effector cells and can be force-sensitive ion channels, G protein and tyrosine kinase, integrin receptors and the cytoskeleton and many other ways to feel the vivo and in vitro mechanical stimulation and mechanical stimulation signals into cellular biochemical signals, mediated by force-related-sensitive gene expression, synthesis of various enzymes and other active substances, the activation cascade of signaling networks involved in a series of complex physiological and pathological events. Domestic and foreign mechanical stretch stress on osteoblasts in vitro studie