Medium-term clinical and pathological factors and the relationship between meningioma.doc

 PAGE \* MERGEFORMAT 12 Medium-term clinical and pathological factors and the relationship between meningioma Of: CRITICAL Xiaxiang Guo △, Xu, ZENG Yi, Han Yang Yun, Liu Lun Bo, Luo Xiaoqiang [Abstract] Objective To investigate the midkine (MK protein expression in meningiomas and its relationship to clinical pathology. Methods SP immunohistochemistry, detected in 52 cases of meningioma and 10 cases of normal meningeal tissue of MK protein expression and statistically analyzed the relationship between the two. Results 52 cases of meningioma, MK protein expression rate was 63.5%, normal meningeal tissue no MK protein expression, the difference was significant (P = 0.001 lt;0.05). MK protein expression and patient age, sex and tumor location, size, shape, independent of (rs = 0.4524, P = 0.089gt; 0.05), but not with tumor grade classification (rs = 0.3785, P = 0.0024 lt;0.05), invasive (rs = 0.7412, P = 0.0087 lt;0.05), blood supply (rs = 0.6518, P = 0.041 lt;0.05), edema (rs = 0.6142, P = 0.032 lt;0.05) are closely related. Conclusion MK protein in meningioma There are overexpressed, MK protein expression and invasive behavior, tumor-related edema and pathological grade, MK protein is expected to become the clinical behavior of meningiomas to determine the biological indicators. inhibit the expression of MK, is expected to high expression of MK’s meningiomas provide a new therapeutic approach. [Keywords:] Meningioma protein midkine (MK human primitive hematopoietic cells (CD34 microvessel density (MVD immunohistochemistry Abstract Objective To discuss the expresion of midkine (MK) in meningioma and its relation with the clinicopathology of meningioma.Methods SP immunohistochemistry was applied in detecting the expression of MK in meningioma tissues of 52 cases and in normal dura tissues of 10 cases, and a statistical analysis was made to the relation between the two.Results In the meningioma tissues, the positive rate of the MK expression was 63.5% w