Mesangial cells TNF-α NF-κ B and glomerular fibrosis.doc

 PAGE \* MERGEFORMAT 15 Mesangial cells TNF-α NF-κ B and glomerular fibrosis [Abstract] Renal fibrosis is the most immune and non-immune kidney disease a common pathological feature of many progressive renal diseases, loss of renal function in the final pathway. Mesangial cells is to maintain the normal glomerular structure and function of the needs of one of three kinds of glomerular cells, glomerular cells, including the following light, TNF-α , NF-κ B in glomerular fibrosis in the process of intrinsic relationship between . [Keywords:] mesangial cells; TNF-α ; NF-κ B; glomerular fibrosis Renal fibrosis is the most immune and non-immune kidney disease a common pathological feature of many progressive renal diseases, loss of renal function in the final pathway. When the renal fibrosis has already started, do not give proper treatment, then even if at the start after the removal of pathogenic factors of fibrosis will be, indicating secondary mechanism in the follow-up of renal injury plays an important role in [1 , 2]. In recent years, due to the development of cellular and molecular biology techniques to promote the study of renal cell biology in-depth, thereby confirming renal cell activation and proliferation of progress of nephropathy, the development has an important impact. In chronic progressive glomerular diseases, glomerular intrinsic cells, target cells are not only victims, but also produce a variety of cell activation by cytokines, growth factors and other molecules involved in the regulation of active disease, the development process. They can direct synthesis of ECM, is also capable of producing proteases regulate ECM metabolism. A glomerular mesangial cells Mesangial cells is to maintain the normal glomerular structure and function of the needs of one of three kinds of glomerular cells, mesangial cells now known to have at least two kinds, one is a smooth muscle-like cells, accounting for the vast majority, in order to glomerular in