Mesenchymal stem cells immune regulation of research.docVIP

 PAGE \* MERGEFORMAT 7 Mesenchymal stem cells immune regulation of research [Keywords:] mesenchymal stem cell; immune regulation; Review Stem cell research hotspot in recent years, bone marrow, in addition to blood stem cells, it also contains another type of stem cells - mesenchymal stem cells (mesenchymal stem cells, MSC). Phase-contrast microscope observations of MSC cultured fibroblasts similar to the group and has strong self-proliferation and multilineage differentiation potential. When subcultured, MSC showed a high degree of expansion of capacity, and still maintained a cell chromosome karyotype and telomere activity [1]. Induced in different conditions, with the mesoderm and neuroectodermal differentiation capacity of cells, such as to differentiate into bone cells, cartilage cells, fat cells, fibroblasts, endothelial cells, nerve cells and supporting stromal cells and other hematopoietic differentiation [2,3]. In recent years, studies have found, MSC immunogenicity is weak, in the body not only fail to induce immune response, but also inhibit the immune response role. The author in recent years, the immunomodulatory effects of MSC and its mechanisms are reviewed. 1 MSC sources MSC in morphology was spindle-shaped fibroblast-like cells, can be attached to plastic or glass dish on the growth and colony formation of uniform or adherent of the convergence layer, is derived from the mesoderm that has multi-directional differentiation potential of stem cells, the main exist in the body interstitial connective tissue and organs. At present most reports of adult bone marrow MSC, are easy to attached to plastic culture plate surface characteristics, bone marrow MSC content is extremely low, about every 104 to 105 mononuclear cells contain one, but its expansion capability is very strong, its doubling time in exponential phase of growth takes about 30 ~ 33 h, in vivo human bone marrow MSC can be maintained on behalf of the rumored 40 stem cell characterist